Sodium Hydroxide → 1-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine

HRID 2263188

反応式

HRID 2263188 の反応式
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 687781261-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride

生成物 1

HCID 80272011-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine収率 89%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride (1.00 g, 2.97 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (696 mg, 67.2%) as an oil.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-1f68d41a50c640ff88e42ef17cbce328
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

関連ノート

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