Methanol → Pyrrolidinone, (4-aminophenyl)-

HRID 2263231

反応式

HRID 2263231 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1)([O-])=O.CO>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 887MethanolHCID 2993281-(4-Nitrophenyl)pyrrolidin-2-one

生成物 1

HCID 676146Pyrrolidinone, (4-aminophenyl)-収率 92.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1-(4-nitrophenyl)pyrrolidin-2-one (1.00 g, 4.85 mmol), 10% palladium on carbon (100 mg), methanol (20 ml) and tetrahydrofuran (20 ml) was stirred under hydrogen atmosphere for 12 hours, insoluble substances were removed by filtration, and the filtrate was concentrated to give 790 mg (92.5%) of the desired product as an oil.

後処理

  1. custominsoluble substances were removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-e710ceef379b475083c097f649ae98ea
出典データセット
uspto-grants-2010_12
特許番号
US07851473B2

関連ノート

読み込み中…