Water → 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole

HRID 2264592

反応式

HRID 2264592 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[CH:12]3)[CH:3]=1.[N-:18]=[N+:19]=[N-:20].[Na+].O>CN(C=O)C>[N:18]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[CH:12]3)[CH:3]=1)=[N+:19]=[N-:20]

参加物

5

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 574551565-((6-Chloropyrimidin-4-yl)oxy)-1H-indole

生成物 1

HCID 862347045-(6-Azido-pyrimidin-4-yloxy)-1H-indole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

490 mg (2.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) and 260 mg (4.0 mMol) NaN3 in 3 ml DMF are stirred for 3 h at 90° C. Then the reaction mixture is poured into water and extracted three times with EtOAc. The organic layers are washed twice with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: MS: [M+1]+=253.

後処理

  1. extractionextracted three times with EtOAc
  2. washThe organic layers are washed twice with water and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-15e27e7259fb44428da90c0ce67e12f8
出典データセット
uspto-grants-2010_12
特許番号
US07855215B2

関連ノート

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