Sodium Hydroxide → 5-(2-Amino-pyrimidin-4-yloxy)-2,3-dihydro-1H-indole
反応式
[NH2:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[CH:12]3)[CH:5]=[CH:4][N:3]=1.[BH3-]C#N.[Na+].[OH-].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH2:13][CH2:12]3)[CH:5]=[CH:4][N:3]=1参加物
5
実験手順
A solution of 160 mg (0.70 mMol) of 5-(2-amino-pyrimidin-4-yloxy)-1H-indole in 4 ml acetic acid is cooled to 10-15° C. Then 222 mg (3.5 mMol) NaBH3CN are added. After 1 h stirring at rt, 8 g of ice are added. Then the mixture is made basic by addition of 1 N NaOH and extracted three times with EtOAc. The organic layers are washed with water and brine, dried (Na2SO4) and concentrated at rt in vacuo: MS: [M+1]+=229.
後処理
- extractionextracted three times with EtOAc
- washThe organic layers are washed with water and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated at rt in vacuo
出典と根拠
- ORDレコード
- ord-59d0731eebbc4225b3ea77f6279d2465
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07855215B2
反応ノート
読み込み中…