Lithium Hydroxide → 2-[5-(3-Isopropyl-phenoxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid

温度

30 °C

A mixture of 2-[5-(3-isopropyl-phenoxy)-4′-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoic acid methyl ester (33 mg, 0.07 mmol), THF (0.6 mL), 10% aq. LiOH (0.2 mL) and MeOH (0.6 mL) was stirred at 30° C. for 3 h. The solution was concentrated and the residue was diluted with H2O (1 mL) and then acidified with conc HCl. The aqueous solution was extracted with DCM (3×1 mL) and the organic layers were filtered through PTFE filter. The solution was concentrated in vacuo to give a solid residue. The solid was purified using reverse phase preparative HPLC (MeCN, H2O) to afford the title compound (21.6 mg, 67%).

1. concentrationThe solution was concentrated
2. additionthe residue was diluted with H2O (1 mL)
3. extractionThe aqueous solution was extracted with DCM (3×1 mL)
4. filtrationthe organic layers were filtered through PTFE
5. filtrationfilter
6. concentrationThe solution was concentrated in vacuo
7. customto give a solid residue
8. customThe solid was purified

ORDレコード

ord-210d2b5c6a9b46f0ace5995b0b7ec125

出典データセット

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07557244B2