Water → 2-Amino-4,5-dichlorobenzoic acid

HRID 2265170ノート

反応式

HRID 2265170 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].O.[Li+].[OH-]>C1COCC1>[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 11694243Methyl 2-amino-4,5-dichlorobenzoate

生成物 1

HCID 121045502-Amino-4,5-dichlorobenzoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 2-amino-4,5-dichlorobenzoate (2.1 g, 9.41 mmol) was dissolved in THF (15 mL) and water (30 mL) was added. LiOH (0.79 g, 18.8 mmol) was added the mixture was stirred overnight at rt. The product was precipitated by addition of 10% aq. HCl (30 mL) and isolated by suction filtration. The white solid was dried under vacuum (1.6 g, 81%). 1H NMR (400 MHz, DMSO-d6): 7.78 (s, 1H), 7.01 (s, 1H).

後処理

  1. customThe product was precipitated by addition of 10% aq. HCl (30 mL)
  2. customisolated by suction filtration
  3. customThe white solid was dried under vacuum (1.6 g, 81%)

出典と根拠

ORDレコード
ord-53b126169da841e7a3a20b968616c29c
出典データセット
uspto-grants-2010_12
特許番号
US07855292B2

反応ノート

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