Hydrochloric Acid → [8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methyl-quinolin-5-yloxy]acetic Acid

HRID 2266474ノート

反応式

HRID 2266474 の反応式
C[O:2][C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8]([O:26][CH:27]([F:29])[F:28])=[C:9]([S:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:10]([CH3:17])=[N:11]2.[OH-].[Na+].Cl>O1CCCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:30])=[O:2])=[C:7]2[C:12]=1[N:11]=[C:10]([CH3:17])[C:9]([S:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)=[C:8]2[O:26][CH:27]([F:28])[F:29]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68780463[8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methylquinolin-5-yloxy]acetic Acid Methyl Ester

生成物 1

HCID 57742534[8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methyl-quinolin-5-yloxy]acetic Acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of [8-chloro-3-(4-chlorophenylsulfanyl)-4-difluoromethoxy-2-methylquinolin-5-yloxy]acetic acid methyl ester (0.044 g), tetrahydrofuran (3.0 mL) and 1.0 M aqueous sodium hydroxide solution (0.15 mL) was stirred at room temperature for 1 hour. The solution was acidified by the addition of 1.0 M aqueous hydrochloric acid and the solvent removed under reduced pressured. The residue was diluted with ethyl acetate and this mixture washed with water and then dried over magnesium sulfate. The solvent was removed under reduced pressure and the resulting solid washed with dichloromethane and dried to afford title compound, 0.024 g.

後処理

  1. customthe solvent removed
  2. additionThe residue was diluted with ethyl acetate
  3. washthis mixture washed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was removed under reduced pressure
  6. washthe resulting solid washed with dichloromethane
  7. customdried

出典と根拠

ORDレコード
ord-f3cd9a5d3112483b944eb766f8fd4a39
出典データセット
uspto-grants-2010_12
特許番号
US07858640B2

反応ノート

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