Lithium Hydroxide → HCID 57742510、化合物
反応式
C[O:2][C:3](=[O:32])[C:4]([O:7][C:8]1[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]2[C:9]=1[C:10]([CH3:31])=[C:11]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=1)[C:12]([O:19][CH:20]([F:22])[F:21])=[N:13]2)([CH3:6])[CH3:5].[OH-].[Li+]>O1CCCC1>[Cl:18][C:15]1[CH:16]=[CH:17][C:8]([O:7][C:4]([CH3:6])([CH3:5])[C:3]([OH:32])=[O:2])=[C:9]2[C:14]=1[N:13]=[C:12]([O:19][CH:20]([F:21])[F:22])[C:11]([CH2:23][C:24]1[CH:25]=[CH:26][C:27]([Cl:30])=[CH:28][CH:29]=1)=[C:10]2[CH3:31]参加物
4
実験手順
A mixture of 2-[8-chloro-3-(4-chlorobenzyl)-2-difluoromethoxy-4-methylquinolin-5-yloxy]-2-methylpropionic acid methyl ester (0.030 g), tetrahydrofuran (2.0 mL) and 1.0 M aqueous lithium hydroxide solution (2.0 mL) was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, diluted with water and the pH adjusted to 4 by the addition of sodium dihydrogenphosphate. The mixture was extracted with ethyl acetate and the combined extracts dried over magnesium sulfate. The solvent was removed under reduced pressure to afford title compound, 0.027 g.