反応式
[C:1]([C:4]1[CH:26]=[CH:25][C:7]([O:8][CH2:9][C:10]2[CH:11]=[C:12]([S:16][C:17]3[CH:18]=[C:19]([CH:22]=[CH:23][N:24]=3)[C:20]#[N:21])[CH:13]=[CH:14][CH:15]=2)=[C:6]([CH2:27][CH2:28][CH3:29])[C:5]=1[OH:30])(=[O:3])[CH3:2].[N-:31]=[N+:32]=[N-:33].[Na+].Cl.C(N(CC)CC)C>>[OH:30][C:5]1[C:6]([CH2:27][CH2:28][CH3:29])=[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16][C:17]3[CH:18]=[C:19]([C:20]4[N:31]=[N:32][NH:33][N:21]=4)[CH:22]=[CH:23][N:24]=3)[CH:11]=2)[CH:25]=[CH:26][C:4]=1[C:1](=[O:3])[CH3:2]参加物
4
実験手順
Employing the procedure essentially as described in Example 1 using 2-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenylsulfanyl]-isonicotinonitrile (380 mg, 0.908 mmol), sodium azide (590 mg, 9.08 mmol), and triethylamine hydrochloride (1.25 g, 9.08 mmol), the title compound is obtained as a white solid (261 mg, 62%): 1H NMR (DMSO-d6) δ 0.760 (t, 3H), 1.39 (sextuplet, 2H), 2.52 (t, 2H), 2.56 (s, 3H), 5.32 (s, 2H), 6.71 (d, 1H), 7.59 (m, 4H), 7.73 (m, 2H), 7.79 (d, 1H), 8.64 (d, 1H), 12.82 (s, 1H); MS (esi negative) m/z 460 (m−1).
出典と根拠
- ORDレコード
- ord-30d6854ae7964fc5bdc621314bf9741d
- 出典データセット
- uspto-grants-2010_12
- 特許番号
- US07858646B2
関連ノート
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