Thionyl Chloride → (2-Chlorophenyl)(4-chlorophenyl)methyl chloride

HRID 2267956

反応式

HRID 2267956 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)O.S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([Cl:19])[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 247332(2-Chlorophenyl)(4-chlorophenyl)methanol

生成物 1

HCID 247330(2-Chlorophenyl)(4-chlorophenyl)methyl chloride収率 102.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A stirred solution of 9.0 grams (0.036 mole) of (2-chlorophenyl)(4-chlorophenyl)methanol in 90 mL of chloroform was cooled to 0° C., and 5.3 mL (0.072 mole) of thionyl chloride was added. Upon completion of the addition the reaction mixture was allowed to warm to ambient temperature, where it stirred for about 18 hours. After this time the reaction mixture was filtered and concentrated under reduced pressure. The filtrate was taken up in hexane and subjected to column chromatography on silica gel with hexane as eluant. The product-containing fractions were combined and concentrated under reduced pressure, yielding 10.0 grams of (2-chlorophenyl)(4-chlorophenyl)methyl chloride. The NMR spectrum was consistent with the proposed structure.

後処理

  1. additionUpon completion of the addition the reaction mixture
  2. filtrationAfter this time the reaction mixture was filtered
  3. concentrationconcentrated under reduced pressure
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a81c024108954c3da6b384adb0a4da93
出典データセット
uspto-grants-2001_12
特許番号
USH0002007H1

関連ノート

読み込み中…