Water → Allyl 4-formylbenzoate

HRID 2268212ノート

反応式

HRID 2268212 の反応式
[H-].[Na+].[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH2:14](Br)[CH:15]=[CH2:16].O>CN(C=O)C>[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][CH2:16][CH:15]=[CH2:14])=[O:10])=[CH:7][CH:6]=1)=[O:4]

参加物

6

反応物 4

HCID 962WaterHCID 7841Allyl bromideHCID 120884-Formylbenzoic acidHCID 24758Sodium hydride

生成物 1

HCID 18381245Allyl 4-formylbenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

3.8 g (12 mmol) of sodium hydride (80% in oil) and 100 ml of DMF are introduced into a three-necked flask under a stream of nitrogen. A solution of 15 g (10 mmol) of 4-formylbenzoic acid in 100 ml of DMF is added dropwise and the mixture is stirred until the evolution of gas has ceased. 10 ml (12 mmol) of allyl bromide are then added and the mixture is stirred at room temperature for four hours. The reaction medium is poured into water and extracted with ethyl ether, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. 17.2 g (90%) of the expected allyl ester are collected in the form of a yellow oil.

後処理

  1. stirringthe mixture is stirred at room temperature for four hours
  2. extractionextracted with ethyl ether
  3. customthe organic phase is separated out after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom17.2 g (90%) of the expected allyl ester are collected in the form of a yellow oil

出典と根拠

ORDレコード
ord-1674d0cdf5134149b582b907c3e60340
出典データセット
uspto-grants-2001_12
特許番号
US06326510B1

反応ノート

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