Water → 2-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol

HRID 2268243ノート

反応式

HRID 2268243 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][CH2:13][CH2:14][N:15]([CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)[CH2:16][C:17](OC)=[O:18])=[CH:10][CH:9]=1.O.[OH-].[Na+]>C1COCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][N:15]([CH2:16][CH2:17][OH:18])[CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)=[CH:29][CH:30]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 18349617HCID 18349617、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 183497742-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Lithium aluminium hydride (0.23 g) was added to a solution of methyl N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]glycinate (1.30 g) in THF (30 ml). The mixture was boiled under reflux for 4 hours and then cooled. Water (1 ml) was added followed by 5M sodium hydroxide solution (2 ml) and then more water (2 ml). The mixture was filtered to remove the precipitate using a filtration aid. The filtrate was washed with water, dried and evaporated to give 2-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol as an oil.

後処理

  1. temperatureunder reflux for 4 hours
  2. temperaturecooled
  3. filtrationThe mixture was filtered
  4. customto remove the precipitate
  5. washThe filtrate was washed with water
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-7eff432d2eb241acb9f3996145bb7004
出典データセット
uspto-grants-2001_12
特許番号
US06326500B1

反応ノート

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