N-bromobutanimide → 1-Bromo-6-bromomethyl-2,3,4,5-tetramethoxybenzene

反応式

[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([O:9][CH3:10])[C:5]([O:11][CH3:12])=[C:4]([O:13][CH3:14])[C:3]=1[O:15][CH3:16].[Br:17]N1C(=O)CCC1=O>CC(N=NC(C#N)(C)C)(C#N)C.C(OCC)(=O)C>[Br:1][C:2]1[C:7]([CH2:8][Br:17])=[C:6]([O:9][CH3:10])[C:5]([O:11][CH3:12])=[C:4]([O:13][CH3:14])[C:3]=1[O:15][CH3:16]

参加物

実験手順

An ethyl acetate (300 ml) solution of 1-bromo-2,3,4,5-tetramethoxy-6-methylbenzene (49.5 g, 0.170 mols), N-bromosuccinimide (31.8 g, 0.179 mols) and AIBN (558 mg, 3.40 mmols) was heated under reflux for 1 hour. The reaction mixture was concentrated in vacuo, and then diluted with hexane. The resulting crystals were separated by filtration, and the filtrate was concentrated to obtain the entitled compound (62.6 g) as an oil.