Benzoyl Peroxide → N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide

反応式

[F:1][C:2]([F:14])([F:13])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)=[O:4].CC1N=C(N)C=CC=1.FC(F)(F)C(OC(=O)C(F)(F)F)=O.[Br:36]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[Br:36][CH2:12][C:8]1[N:7]=[C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:13])[F:14])[CH:11]=[CH:10][CH:9]=1

参加物

反応物 5

HCID 7187Benzoyl Peroxide

HCID 9845Trifluoroacetic anhydride

HCID 157652-Amino-6-methylpyridine

HCID 67184N-bromobutanimide

HCID 36439582,2,2-trifluoro-N-(6-methylpyridin-2-yl)acetamide2 回

生成物 1

HCID 57754672N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide

試薬・触媒・溶媒 2

実験手順

2,2,2-trifluoro-N-(6-methyl-pyridin-2-yl)-acetamide xxii can be prepared from 6-methyl-pyridin-2-ylamine and trifluoroacetic anhydride in DCM. Radical bromination of xxii with N-bromosuccinimide and benzoyl peroxide in refluxing carbon tetrachloride affords N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide xxiii.