Hydrochloric Acid → 3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid

HRID 2269769ノート

反応式

HRID 2269769 の反応式
C([O:3][C:4](=[O:19])[C:5]([CH3:18])=[CH:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[NH2:17])C.[OH-].[Na+].Cl>O1CCCC1>[NH2:17][C:8]1[CH:9]=[C:10]([O:15][CH3:16])[C:11]([O:13][CH3:14])=[CH:12][C:7]=1[CH:6]=[C:5]([CH3:18])[C:4]([OH:19])=[O:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702131123-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester

生成物 1

HCID 702156293-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Into 10 ml of tetrahydrofuran (THF), 1.0 g of (E) 3-(2-amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted at 40° C. for 4 hours. After the completion of the reaction, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto, and the precipitated crystal was filtered out, whereby 0.85 g of the aimed compound was obtained (95%).

後処理

  1. customthe mixture was reacted at 40° C. for 4 hours
  2. customAfter the completion of the reaction
  3. additionadded
  4. filtrationthe precipitated crystal was filtered out

出典と根拠

ORDレコード
ord-12aae317bcaf4e89b3df564d430e6cf6
出典データセット
uspto-grants-2001_12
特許番号
US06329546B1

反応ノート

読み込み中…