p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
反応式
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]参加物
4
実験手順
To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.
後処理
- temperatureby heating
- temperaturerefluxing for 2.5 hours
- temperatureAfter cooling
- extractionthe mixture was extracted with diethyl ether
- dry with materialThe extract was dried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-991ad80c1386408da891fc79a06e5c96
- 出典データセット
- uspto-grants-2001_12
- 特許番号
- US06333431B1
反応ノート
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