Esomeprazole → HCID 178488151、化合物

HRID 227278

反応式

HRID 227278 の反応式
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][S@@:12]([C:14]2[NH:18][C:17]3[CH:19]=[C:20]([O:23][CH3:24])[CH:21]=[CH:22][C:16]=3[N:15]=2)=[O:13])=[N:4][CH:3]=1.[CH:25]1([C@H:31]([NH2:33])[CH3:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>C(#N)C>[CH:25]1([C@H:31]([NH3+:33])[CH3:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:16]2[NH:15][C:14]([S@:12]([CH2:11][C:5]3[C:6]([CH3:10])=[C:7]([O:8][CH3:9])[C:2]([CH3:1])=[CH:3][N:4]=3)=[O:13])=[N:18][C:17]=2[CH:19]=1

参加物

4

反応物 2

HCID 9568614EsomeprazoleHCID 10997046(1R)-1-Cyclohexylethanamine

生成物 1

HCID 178488151HCID 178488151、化合物収率 36.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

(S)-omeprazole (1.0 g, 2.9 mmol) was dissolved in acetonitrile (10 ml). (R)-1-cyclohexyl ethyl amine (0.83 ml, 5.7 mmol) was added to the solution whereupon a white solid precipitated. After 45 minutes acetonitril (10 ml) was added to the thick reaction mass and stirring was continued for 45 minutes. The precipitate was filtered off, washed with acetonitrile, and dried. 0.5 g of the title compound was obtained.

後処理

  1. customprecipitated
  2. additionAfter 45 minutes acetonitril (10 ml) was added to the thick reaction mass
  3. filtrationThe precipitate was filtered off
  4. washwashed with acetonitrile
  5. customdried

出典と根拠

ORDレコード
ord-ef8b32b7427c427c9f0cb2876b38390a
出典データセット
uspto-grants-2009_07
特許番号
US07560472B2

関連ノート

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