Phenethylamine → (2-Phenylethyl)propylamine
反応式
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10](I)[CH2:11][CH3:12].C(N(CC)CC)C>O1CCCC1>[CH2:10]([NH:9][CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:11][CH3:12]参加物
5
実験手順
1.2 ml (9.5 mmol) of phenylethylamine, 0.93 ml (9.5 mmol) of n-propyl-iodide, 5 ml of triethylamine and 5 ml of THF (tetrahydrofuran) were placed in a flask, and the reaction mixture was heated at reflux temperature of the reaction mixture for 3.5 hours and then cooled. A salt formed was filtered off, the solution was evaporated and a desired compound was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:3). This yields 0.62 g (40%) of N-propyl-(β-phenylethyl)amine in the form of the oil (molecular weight: 163.264, formula: C11H17N).
後処理
- temperaturethe reaction mixture was heated
- temperatureat reflux temperature of the reaction mixture for 3.5 hours
- temperaturecooled
- customA salt formed
- filtrationwas filtered off
- customthe solution was evaporated
- customa desired compound was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:3)
出典と根拠
- ORDレコード
- ord-782d417f33de43f2bb4ffa61161c59ce
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07560474B2
反応ノート
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