Ammonium formate → 1-N-(2-methoxyethyl)benzene-1,2-diamine
反応式
C([O-])=O.[NH4+].[CH3:5][O:6][CH2:7][CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O>[Pd].CO>[CH3:5][O:6][CH2:7][CH2:8][NH:9][C:10]1[C:11]([NH2:16])=[CH:12][CH:13]=[CH:14][CH:15]=1参加物
5
実験手順
Ammonium formate (727 mg, 11.3 mmol) followed by a catalytic amount of palladium on carbon (5%) is added to a solution of N-(2-methoxyethyl)-2-nitroaniline (426 mg, 2.17 mmol) in methanol. The mixture may be refluxed for an appropriate time period (such as overnight), cooled to an appropriate temperature (such as room temperature) and filtered. The filtrate may be concentrated and the residue may purified by Biotage column chromatography to give N1-(2-methoxyethyl)benzene-1,2-diamine (319 mg)
後処理
- temperatureThe mixture may be refluxed for an appropriate time period (such as overnight)
- filtrationfiltered
- concentrationThe filtrate may be concentrated
- customthe residue may purified by Biotage column chromatography
出典と根拠
- ORDレコード
- ord-937e34ca3b234f7fba1c9fe743faf356
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09125901B2
反応ノート
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