Sodium Hydroxide → N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine

HRID 2276395ノート

反応式

HRID 2276395 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.[OH-:13].[Na+].[NH2:15]O.Cl>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[N:15][OH:13]

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 679903-(Trifluoromethyl)benzaldehydeHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 2777383N-{[3-(Trifluoromethyl)phenyl]methylidene}hydroxylamine収率 93.5%

実験手順

In a similar manner as described in Preparation Example 1, by using 3-(trifluoromethyl)benzaldehyde (34.82 g, 200.0 mmol), sodium hydroxide (12.00 g, 300.0 mmol) and hydrochloric acid hydroxylamine (16.68 g, 240 mmol), a white solid required compound (35.33 g, 187 mmol, 93%) was obtained.

後処理

  1. customIn a similar manner as described in Preparation Example 1

出典と根拠

ORDレコード
ord-49dfc682bb7a436ca053255ec074e786
出典データセット
uspto-grants-2015_09
特許番号
US09132126B2

反応ノート

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