Ethyl Acetate → 4-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide

HRID 2277178ノート

反応式

HRID 2277178 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][C:3]=1[NH2:9].[CH:10]1([CH2:13][O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=2)[CH2:12][CH2:11]1.C(OCC)(=O)C>N1C=CC=CC=1.C1COCC1>[CH:10]1([CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([NH:9][C:3]3[CH:4]=[N:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[O:20])=[CH:22][CH:23]=2)[CH2:12][CH2:11]1

参加物

6

反応物 3

HCID 8857Ethyl AcetateHCID 5957294,6-Dichloropyridin-3-amineHCID 867312344-(Cyclopropylmethoxy)benzoyl chloride

生成物 1

HCID 867312334-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide収率 36.3%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4,6-dichloropyridin-3-amine (2.00 g) in pyridine (30 mL) was added a solution of 4-(cyclopropylmethoxy)benzoyl chloride (3.88 g) in THF (5 mL), and the mixture was stirred at room temperature for 10 min. The reaction mixture was subjected to silica gel column chromatography (NH, ethyl acetate), and the solvent was evaporated, and the obtained solid was washed with diethyl ether/hexane to give the title compound (1.50 g).

後処理

  1. customthe solvent was evaporated
  2. washthe obtained solid was washed with diethyl ether/hexane

出典と根拠

ORDレコード
ord-66fdf7dd845747758c5b14d7fc8c2717
出典データセット
uspto-grants-2015_09
特許番号
US09133129B2

反応ノート

読み込み中…