Oxalyl chloride → 4-(Cyclopropylmethoxy)-3-fluorobenzoyl chloride
反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:19])=O>C1COCC1.CN(C=O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10]([Cl:19])=[O:11])=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1参加物
5
実験手順
To a solution of 4-(cyclopropylmethoxy)-3-fluorobenzoic acid (1.57 g) in THF (50 mL) were added oxalyl dichloride (0.982 mL) and DMF (2 drops), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure to give 4-(cyclopropylmethoxy)-3-fluorobenzoyl chloride. This compound was used for the next reaction without further purification.
後処理
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-5d20af099d34407f9ba706d37a4467ca
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133129B2
反応ノート
読み込み中…