3-Chloro-2-fluorobenzaldehyde → 3-Chloro-2-fluorobenzyl alcohol

HRID 2277575ノート

反応式

HRID 2277575 の反応式
[F:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C1COCC1.C(Cl)Cl>[Cl:10][C:9]1[C:2]([F:1])=[C:3]([CH2:4][OH:5])[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 7363353-Chloro-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 27736063-Chloro-2-fluorobenzyl alcohol

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-fluoro-3-chloro-benzaldehyde (4.74 g, 30 mmol) in THF (20 mL) was added NaBH4 (1.48 g, 40 mmol). The resulting mixture was stirred at room temperature for 30 min before diluting with DCM. The organic layer was washed with water and brine. The combined organic layers were dried over anhy. Na2SO4, filtered and concentrated in vacuo to give desired product without further purification (4.8 g, 100%). MS: 161.0 (M+H)+.

後処理

  1. washThe organic layer was washed with water and brine
  2. customThe combined organic layers were dried over anhy
  3. filtrationNa2SO4, filtered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-eee0d38234e948a18495c89494babee2
出典データセット
uspto-grants-2015_09
特許番号
US09133158B2

反応ノート

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