Hydrochloric Acid → 5-Bromo-2-formylbenzoic acid

HRID 2278287ノート

反応式

HRID 2278287 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[O:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Li+].O1CCCC1.Cl>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[O:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 53419722Methyl 5-bromo-2-formylbenzoate

生成物 1

HCID 6038605-Bromo-2-formylbenzoic acid収率 74.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 50 mL round-bottom flask was charged with methyl 5-bromo-2-formylbenzoate (1.00 g, 4.11 mmol, 1.00 equiv), lithium hydroxide (2.00 g, 83.5 mmol, 20.0 equiv), tetrahydrofuran (10 mL), and H2O (10 mL). The resulting solution was stirred for 3 h at room temperature. The pH value of the solution was adjusted to 6 with hydrogen chloride solution (2 mol/L). The solid were collected by filtration to yield 0.700 g (crude) of 5-bromo-2-formylbenzoic acid as a light yellow solid. LCMS (ESI, m/z): 227 [M−H]−.

後処理

  1. filtrationThe solid were collected by filtration

出典と根拠

ORDレコード
ord-80f360a3fb39420d9a5df1cadabe73bf
出典データセット
uspto-grants-2015_09
特許番号
US09133148B2

反応ノート

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