Sodium Hydroxide → HCID 57388439、化合物
反応式
[OH-].[Na+:2].C[O:4][C:5](=[O:22])[CH2:6][C:7]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([F:15])=[C:9]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[N:8]=1>C1COCC1>[F:15][C:10]1[C:11]([O:13][CH3:14])=[N:12][C:7]([CH2:6][C:5]([O-:22])=[O:4])=[N:8][C:9]=1[N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1.[Na+:2]参加物
4
実験手順
7.9 ml of 2N sodium hydroxide are added to a solution of 3.46 g of (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid methyl ester in 36 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5 so as to give 3.7 g of sodium (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate, the characteristics of which are the following: