Sodium Hydroxide → Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

HRID 2278484ノート

反応式

HRID 2278484 の反応式
[OH-].[Na+:2].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[NH:9][C:10](=[O:21])[C:11]([F:20])=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:13]=1)C>C1COCC1>[F:20][C:11]1[C:10](=[O:21])[NH:9][C:8]([CH2:7][C:6]([O-:22])=[O:5])=[N:13][C:12]=1[N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1.[Na+:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 136069587(5-Fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester

生成物 1

HCID 136069585Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2.9 ml of 2N sodium hydroxide are added to a solution of 800 mg of (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 10 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 780 mg of sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

後処理

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

出典と根拠

ORDレコード
ord-17a1a48e606046b1b5bd6e5dd52908e4
出典データセット
uspto-grants-2015_09
特許番号
US09133168B2

反応ノート

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