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Pyridine → 6-(morpholin-4-yl)-2-{2-oxo-2-[4-(1-propylpiperidin-3-yl)-2,3-dihydro-1H-indol-1-yl]ethyl}pyrimidin-4(3H)-one

HRID 2278617
ノート
印刷プレビュー

反応式

HRID 2278617 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[N:8]1[C:13](=[O:14])[CH:12]=[C:11]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:10]=[C:9]1[CH2:21][C:22](=[O:36])[N:23]1[C:31]2[C:26](=[C:27](C(F)(F)F)[CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1.Cl.CN(C)[CH2:40][CH2:41][CH2:42]N=C=NCC.N1(C2N=C(CC([O-])=O)NC(=O)C=2)CCOCC1.[Na+]>CN(C)C=O>[N:15]1([C:11]2[N:10]=[C:9]([CH2:21][C:22](=[O:36])[N:23]3[C:31]4[C:26](=[C:27]([CH:3]5[CH2:4][CH2:5][CH2:6][N:1]([CH2:40][CH2:41][CH3:42])[CH2:2]5)[CH:28]=[CH:29][CH:30]=4)[CH2:25][CH2:24]3)[NH:8][C:13](=[O:14])[CH:12]=2)[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 1049PyridineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 573895513-methyl-6-(morpholin-4-yl)-2-{2-oxo-2-[4-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]ethyl}pyrimidin-4(3H)-oneHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

生成物 1

HCID 136069607
6-(morpholin-4-yl)-2-{2-oxo-2-[4-(1-propylpiperidin-3-yl)-2,3-dihydro-1H-indol-1-yl]ethyl}pyrimidin-4(3H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.2 ml of pyridine, 25.7 mg of 4-(1-propylpiperidin-3-yl)-2,3-dihydro-1H-indole (reference example 4d) and 17.8 mg of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride are successively added to a solution of 20.5 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d) in 0.8 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 24 hours, and then concentrated under reduced pressure. The residue is taken up in 10 ml of water and then extracted with dichloromethane (4×20 ml). The organic phases are combined and then washed with water and concentrated under reduced pressure. After oven-drying, 16.1 mg of 6-(morpholin-4-yl)-2-{2-oxo-2-[4-(1-propylpiperidin-3-yl)-2,3-dihydro-1H-indol-1-yl]ethyl}pyrimidin-4(3H)-one are obtained in the form of a pink solid, the characteristics of which are the following:

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with dichloromethane (4×20 ml)
  3. washwashed with water
  4. concentrationconcentrated under reduced pressure
  5. customAfter oven-drying

出典と根拠

ORDレコード
ord-8d04c01b63fa452b91cc7a9647e1e84c
出典データセット
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09133168B2

反応ノート

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