Methanol → (2-Methylpyrimidin-5-yl)methanol

HRID 2278727

反応式

HRID 2278727 の反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][N:3]=1.CO.[BH4-].[Na+]>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][N:3]=1

参加物

4

反応物 3

HCID 887MethanolHCID 31609702-Methylpyrimidine-5-carbaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 14686706(2-Methylpyrimidin-5-yl)methanol

実験手順

A solution of 2-methylpyrimidine-5-carbaldehyde (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0° C. and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.

後処理

  1. customthe reaction was quenched with eq H2O (200 mL)
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-de2a0261964e47fdbe979956c4b1a68e
出典データセット
uspto-grants-2015_09
特許番号
US09133122B2

関連ノート

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