Ethyl Acetate → (2-Methylpyrimidin-5-yl)methanamine

HRID 2278729

反応式

HRID 2278729 の反応式
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[N+]=[N-].C(OCC)(=O)C>[Pd]>[CH3:11][C:8]1[N:9]=[CH:10][C:5]([CH2:4][NH2:1])=[CH:6][N:7]=1

参加物

4

反応物 2

HCID 8857Ethyl AcetateHCID 545950225-(Azidomethyl)-2-methylpyrimidine

生成物 1

HCID 21294601(2-Methylpyrimidin-5-yl)methanamine

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 5-(azidomethyl)-2-methylpyrimidine (55 mg, 0.00037 mol) in ethyl acetate (20 mL, 0.2 mol), and 10% Pd—C (70 mg) was stirred under H2 (1 atm) for 2 hr. The catalyst was filtered off and filtrate was concentrated in vacuo to afford a white solid. LC/MS m/e 124.3 (M+H+)

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated in vacuo
  3. customto afford a white solid

出典と根拠

ORDレコード
ord-ba85c4aa834c45a2993f12ffeb93fcd4
出典データセット
uspto-grants-2015_09
特許番号
US09133122B2

関連ノート

読み込み中…