Lithium Hydroxide → 2'-Fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylic acid

HRID 2278762ノート

反応式

HRID 2278762 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[C:12]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:15]=[C:14]([C:25]([O:27]C)=[O:26])[CH:13]=1.O1CCCC1.[OH-].[Li+]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:9])([F:11])[F:10])[C:3]=1[C:12]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:15]=[C:14]([C:25]([OH:27])=[O:26])[CH:13]=1

参加物

4

反応物 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 67303854Methyl 2'-fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylate

生成物 1

HCID 673043082'-Fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylic acid

反応条件

温度
50 °C

実験手順

A round bottom flask was charged with methyl 2′-fluoro-5-(5-methylpyridin-2-yl)-6′-(trifluoromethyl)biphenyl-3-carboxylate (200.00 mg, 0.51368 mmol), Tetrahydrofuran (7.8 mL, 97 mmol) and Lithium hydroxide (36.906 mg, 1.5410 mmol) and the reaction stirred at room temperature over night and at 50° C. for two days. The reaction mixture was filtered over Sodium sulfate and the solvent removed under reduced pressure to get the acid as brown solid.

後処理

  1. filtrationThe reaction mixture was filtered over Sodium sulfate
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-69c1773f34a748e49a32d17f307e9039
出典データセット
uspto-grants-2015_09
特許番号
US09133122B2

反応ノート

読み込み中…