Sodium hydride → 1-Cyclopropylimidazolidin-2-one
反応式
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][CH:8]1[CH2:10][CH2:9]1)=[O:6].[H-].[Na+]>C1COCC1>[CH:8]1([N:7]2[CH2:2][CH2:3][NH:4][C:5]2=[O:6])[CH2:10][CH2:9]1参加物
4
実験手順
A 0° C. solution of 1-(2-chloroethyl)-3-cyclopropylurea (1.31 g, 8.06 mmol) in THF (40 mL) was treated with NaH (60% in mineral oil, 0.387 g, 9.67 mmol), stirred for 10 minutes, then warmed to RT and stirred for 6 h. The mixture was treated with satd. NH4Cl, the solids removed via filtration and washed with EtOAc. The filtrate was washed with brine, dried over Na2SO4 and concentrated to dryness to afford crude 1-cyclopropylimidazolidin-2-one (760 mg, 75%) which was used without further purification.
後処理
- stirringstirred for 6 h
- additionThe mixture was treated with satd
- customNH4Cl, the solids removed via filtration
- washwashed with EtOAc
- washThe filtrate was washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-b946a33d4cab406c8fa47952e3118f1f
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133183B2
反応ノート
読み込み中…