Ethyl Acetate → HCID 90426016、化合物
反応式
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C@@H:8]([CH3:12])[CH2:9][O:10][CH3:11])=[O:6].[H-].[Na+].CCOC(C)=O>C1COCC1>[CH3:11][O:10][CH2:9][C@H:8]([N:7]1[CH2:2][CH2:3][NH:4][C:5]1=[O:6])[CH3:12]参加物
5
実験手順
A −20° C. solution of (S)-1-(2-chloroethyl)-3-(1-methoxypropan-2-yl)urea (393 mg, 2.019 mmol) in THF (10 mL) was treated portion-wise with NaH (60% in mineral oil, 178 mg, 4.44 mmol), warmed to RT and stirred overnight. The mixture was treated with EtOAc, washed with water, then brine, dried over Na2SO4 and concentrated to dryness to afford crude (R)-1-(1-methoxypropan-2-yl)imidazolidin-2-one (100% yield assumed) which was used without further purification. MS (ESI) m/z: 159.1 (M+H+).
後処理
- washwashed with water
- dry with materialbrine, dried over Na2SO4
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-093c4df1356c406693abfacaf3fa21fc
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133183B2
反応ノート
読み込み中…