1,1,3,3-Tetramethylbutyl isocyanide → [6,8-Dibromo-2-(2,3-dimethoxyphenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethylbutyl)-amine

HRID 22792

反応式

HRID 22792 の反応式
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([Br:9])=[C:4]([CH3:10])[N:3]=1.[CH3:11][C:12]([N+:19]#[C-:20])([CH3:18])[CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15].[CH3:21][O:22][C:23]1[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[CH:27][C:24]=1[CH:25]=O>Cl(O)(=O)(=O)=O>[Br:9][C:5]1[CH:6]=[C:7]([Br:8])[C:2]2[N:3]([C:20]([NH:19][C:12]([CH3:18])([CH3:11])[CH2:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[C:25]([C:24]3[CH:27]=[CH:28][CH:29]=[C:30]([O:31][CH3:32])[C:23]=3[O:22][CH3:21])[N:1]=2)[C:4]=1[CH3:10]

参加物

5

反応物 3

HCID 267251,1,3,3-Tetramethylbutyl isocyanideHCID 665812,3-DimethoxybenzaldehydeHCID 522994Wisteria sinensis, ext.

生成物 1

HCID 9829072[6,8-Dibromo-2-(2,3-dimethoxyphenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]-(1,1,3,3-tetramethylbutyl)-amine

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Compound (6) was prepared according to the general synthesis instructions from 1.0 ml of 2-amino-3,5-dibromo-6-methylpyridine solution (0.1 M, DCM), 0.575 ml of 1,1,3,3-tetramethylbutyl isocyanide solution (0.2 M, DCM), 0.500 ml of 2,3-dimethoxybenzaldehyde solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%).

出典と根拠

ORDレコード
ord-2162421c093a43f59d81760000eb9656
出典データセット
uspto-grants-2005_02
特許番号
US06849642B2

関連ノート

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