Phenylacetyl chloride → 2-Acetyl-3-oxo-4-phenyl-butyric acid methyl ester

HRID 2279640ノート

反応式

HRID 2279640 の反応式
[OH-].[Na+].[CH3:3][C:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])=[O:5].[C:11]1([CH2:17][C:18](Cl)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH3:10][O:9][C:7](=[O:8])[CH:6]([C:4](=[O:5])[CH3:3])[C:18](=[O:19])[CH2:17][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 7679Phenylacetyl chlorideHCID 7757Methyl acetoacetateHCID 14798Sodium Hydroxide

生成物 1

HCID 595798522-Acetyl-3-oxo-4-phenyl-butyric acid methyl ester

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

NaOH (10 N, 4.4 mL, 44 mmol) in H2O is added to a solution of MeCOCH2COOMe (5 g, 43.1 mmol) in THE at RT. PhCH2COCl is added dropwise to the mixture and the mixture is stirred for 14 h. The mixture is extracted with EtOAc (2×30 mL). The organic phase is dried. The product is purified by silica gel column chromatography using 3-5% EtOAc in hexane to afford the title compound.

後処理

  1. extractionThe mixture is extracted with EtOAc (2×30 mL)
  2. customThe organic phase is dried
  3. customThe product is purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-6fe6ffc40f134228a75776eaf7723a58
出典データセット
uspto-grants-2015_09
特許番号
US09133204B2

反応ノート

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