Pyridine → N-(4-chloro-3-nitrophenyl)methanesulfonamide

HRID 2280597ノート

反応式

HRID 2280597 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][S:13](Cl)(=[O:15])=[O:14].N1C=CC=CC=1>C1COCC1.Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][S:13]([CH3:12])(=[O:15])=[O:14])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

参加物

6

反応物 3

HCID 1049PyridineHCID 124774-Chloro-3-nitroanilineHCID 31297Methanesulfonyl chloride

生成物 1

HCID 3755760N-(4-chloro-3-nitrophenyl)methanesulfonamide収率 92.2%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-chloro-3-nitroaniline (5.0 g, 29 mmol), methanesulfonyl chloride (2.37 mL, 30.4 mmol) and pyridine (5.9 mL, 72.4 mmol) in THF (100 mL) was stirred for 24 h. Poured in 1M HCl (500 mL). The resulting precipitate was filtered and air-dried to provide the title compound as a solid (6.7 g, 92%).

後処理

  1. filtrationThe resulting precipitate was filtered
  2. customair-dried

出典と根拠

ORDレコード
ord-ff7cc3558c8a4c9a916f098f2c19f50a
出典データセット
uspto-grants-2015_09
特許番号
US09139536B2

反応ノート

読み込み中…