Tetrahydrofuran → 4-(Methoxycarbonyl)bicyclo(2.2.1)heptane-1-carboxylic acid

温度

15 °C

A 12-L, 3-neck, round bottom flask was equipped with a mechanical stirrer, a J-KEM temperature controller, and a 250 mL addition funnel. The flask was charged with dimethyl bicyclo[2.2.1]heptane-1,4-dicarboxylate (208 g, 980 mmol) and THF (6.7 L). The resulting solution was cooled to 15° C. using an ice/water bath. Sodium hydroxide pellets (39.2 g, 980 mmol) were dissolved in methanol (400 mL) and slowly added to the stirring solution over 30 min. After the addition was complete, white solids began to precipitate. The reaction mixture was stirred at room temp for 16 h when TLC analysis (100% ethyl acetate) indicated about 90% conversion. The reaction mixture was concentrated to dryness, slurried in hexane (2 L), filtered, and washed with hexane (2×400 mL). The resulting sodium carboxylate salt was transferred to a 3-L, 3-neck, round bottom flask equipped with a mechanical stirrer, dissolved in water (1 L), and slowly treated with 2 N aqueous hydrochloric acid (430 mL) at 10° C. until pH ˜4. The thick suspension was diluted with ethyl acetate (1 L) and transferred to a reparatory funnel. The layers were separated and the aqueous layer was further extracted with ethyl acetate (2×500 mL), washed with brine (200 mL), dried over sodium sulfate, and concentrated to provide 170 g (87%) of 4-(methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic acid. 1H NMR (500 Hz, DMSO-d6) δ ppm 12.21 (s, 1H), 3.60 (s, 3H), 1.91 (d, J=6.7 Hz, 4H), 1.75 (s, 2H), 1.56-1.62 (m, 4H).

1. additiona J-KEM temperature controller, and a 250 mL addition funnel
2. additionslowly added to the stirring solution over 30 min
3. additionAfter the addition
4. customto precipitate
5. concentrationThe reaction mixture was concentrated to dryness
6. filtrationfiltered
7. washwashed with hexane (2×400 mL)
8. custom3-neck, round bottom flask equipped with a mechanical stirrer
9. dissolutiondissolved in water (1 L)
10. additionslowly treated with 2 N aqueous hydrochloric acid (430 mL) at 10° C. until pH ˜4
11. additionThe thick suspension was diluted with ethyl acetate (1 L)
12. customtransferred to a reparatory funnel
13. customThe layers were separated
14. extractionthe aqueous layer was further extracted with ethyl acetate (2×500 mL)
15. washwashed with brine (200 mL)
16. dry with materialdried over sodium sulfate
17. concentrationconcentrated

ORDレコード

ord-595cdf1bd79c40b29a64ddf93baa4478

出典データセット

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09139534B2