Ethyl 2-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate → 2-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid

HRID 2281459ノート

反応式

HRID 2281459 の反応式
[CH:1]1([NH:5][C:6]2[C:7]3[CH:32]=[CH:31][NH:30][C:8]=3[N:9]=[C:10]([NH:12][C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]([CH2:23][C:24]([O:26]CC)=[O:25])[C:18](=[O:29])[CH2:17][CH2:16]4)[N:11]=2)[CH2:4][CH2:3][CH2:2]1>C1COCC1.O.[OH-].[Na+]>[CH:1]1([NH:5][C:6]2[C:7]3[CH:32]=[CH:31][NH:30][C:8]=3[N:9]=[C:10]([NH:12][C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]([CH2:23][C:24]([OH:26])=[O:25])[C:18](=[O:29])[CH2:17][CH2:16]4)[N:11]=2)[CH2:2][CH2:3][CH2:4]1

参加物

5

反応物 1

HCID 57990398Ethyl 2-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate

生成物 1

HCID 579903132-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid

試薬・触媒・溶媒 3

HCID 14798Sodium Hydroxide触媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of ethyl 2-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetate (10 mg, 0.023 mmol) in THF (0.6 mL) and H2O (0.4 mL) was added NaOH (5N, 2 drops). After stirring for 3 h at room temperature, the reaction mixture was purified by preparative HPLC to yield 2-(6-(4-(cyclobutyamino)-7H-pyrrolo[2,3-d]pyrimidine-2-ylamino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid (MS calcd for C21H22N6O3 406.2. found [MH] 407.0; UV 207.5, 304.5 nm).

後処理

  1. customthe reaction mixture was purified by preparative HPLC

出典と根拠

ORDレコード
ord-d014616f437047238df88fb5e053866b
出典データセット
uspto-grants-2015_09
特許番号
US09139581B2

反応ノート

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