Trifluoroacetic acid → methyl (2S)-2-amino-3-(quinolin-6-yl)propanoate
反応式
[CH3:1][O:2][C:3]1[C@H:4]([CH2:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[N:21]=[CH:20][CH:19]=[CH:18]3)[N:5]=C(OC)[C@@H](C(C)C)N=1.FC(F)(F)C(O)=[O:28]>O.C(#N)C>[NH2:5][C@@H:4]([CH2:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][CH:19]=[CH:18]2)[C:3]([O:2][CH3:1])=[O:28]参加物
5
反応条件
- 温度
- 10 °C
実験手順
To a solution of #211 (7.3 g, 22.5 mmol, 1 eq.) in water (25 mL) and acetonitrile (80 mL) was added trifluoroacetic acid (9 mL) at 0° C. and the solution was stirred at 10° C. overnight. The organic layer was removed in vacuo and the remaining aqueous layer was basified to pH 9 with sodium carbonate, which was directly used for the next step.
後処理
- customThe organic layer was removed in vacuo
出典と根拠
- ORDレコード
- ord-434e164d28574ed5ac9977da72468d43
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09138486B2
反応ノート
読み込み中…