Chlorosulfonic acid → 4-Fluoro-3-iodobenzenesulfonyl chloride

2-Fluoroiodobenzene (0.58 mL, 5.0 mmol) was added dropwise to chlorosulfonic acid (1.66 mL, 25 mmol) at 0° C. The reaction mixture was allowed to warm to ambient temperature and stirred for 2 hours. The reaction mixture was poured into ice and the mixture was extracted with dichloromethane (3×30 mL). The combined organic layer was dried over magnesium sulfate and concentrated in vacuo to obtain a crude residue. The crude residue was dissolved in heptane (100 mL) and the suspension was filtered. The filtrate was concentrated in vacuo to afford the title compound.

1. additionThe reaction mixture was poured into ice
2. extractionthe mixture was extracted with dichloromethane (3×30 mL)
3. dry with materialThe combined organic layer was dried over magnesium sulfate
4. concentrationconcentrated in vacuo
5. customto obtain a crude residue
6. filtrationthe suspension was filtered
7. concentrationThe filtrate was concentrated in vacuo

ORDレコード

ord-8047d219d85145978962a3fe58a6e321

出典データセット

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09145407B2