Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate → 4-(Propylamino)pyrimidine-5-carboxamide

HRID 2284692ノート

反応式

HRID 2284692 の反応式
C(C1C=CC(N[C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([NH:23]CCCNC(=O)OC(C)(C)C)=[O:22])=[CH:13][N:12]=2)=CC=1)(=O)N>C(Cl)(Cl)Cl.CO.FC(F)(F)C(O)=O>[CH2:18]([NH:17][C:15]1[C:14]([C:21]([NH2:23])=[O:22])=[CH:13][N:12]=[CH:11][N:16]=1)[CH2:19][CH3:20]

参加物

5

反応物 1

HCID 90052173Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate

生成物 1

HCID 1317335334-(Propylamino)pyrimidine-5-carboxamide収率 385.6%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 6212Chloroform溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

To a suspension of tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate (D2, 190 mg) in chloroform (8 mL) and methanol (2 mL), trifluoroacetic acid (1 mL) was added at room temperature, and the mixture was stirred at the same temperature for 30 minutes. The solvent was evaporated under reduced pressure to obtain N-(3-aminopropyl)-2-(4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamide (D3) trifluoroacetate (280 mg).

後処理

  1. additionwas added at room temperature
  2. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-be3a0c69a5e844c48b450b810b856544
出典データセット
uspto-grants-2015_09
特許番号
US09145415B2

反応ノート

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