Sodium Bicarbonate → (S)-tert-butyl (1-((3-(6-((3-fluorophenyl)amino)-4-(propylamino)nicotinamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

反応式

[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:17]=[C:16]([NH:18][CH2:19][CH2:20][CH3:21])[C:12]([C:13]([OH:15])=O)=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:22][C:23]1[CH:24]=[C:25]([NH:29][C:30](=[O:42])[C@@H:31]([N:33]([CH3:41])[C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])[CH3:32])[CH:26]=[CH:27][CH:28]=1.Cl.C(N=C=NCCCN(C)C)C.O.ON1C2C=CC=CC=2N=N1.C(=O)([O-])O.[Na+]>CN(C)C=O.C(N(CC)C(C)C)(C)C>[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:17]=[C:16]([NH:18][CH2:19][CH2:20][CH3:21])[C:12]([C:13]([NH:22][C:23]3[CH:24]=[C:25]([NH:29][C:30](=[O:42])[C@@H:31]([N:33]([CH3:41])[C:34](=[O:40])[O:35][C:36]([CH3:37])([CH3:39])[CH3:38])[CH3:32])[CH:26]=[CH:27][CH:28]=3)=[O:15])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1