Pyridine → HCID 23462409、化合物

HRID 2286726ノート

反応式

HRID 2286726 の反応式
C[C:2]1[N:9]2[C:5]([S:6][CH:7]=[CH:8]2)=[N:4][C:3]=1[CH2:10][OH:11].[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1.N1C=CC=C[CH:23]=1>C(Cl)(Cl)Cl.C(O)(C)C>[ClH:12].[CH3:23][C:8]1[N:9]2[CH:2]=[C:3]([CH2:10][O:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][C:13]([Cl:12])=[CH:14][CH:15]=3)[N:4]=[C:5]2[S:6][CH:7]=1

参加物

6

反応物 3

HCID 1049PyridineHCID 85014-Chlorobenzoyl chlorideHCID 23462415HCID 23462415、化合物

生成物 1

HCID 23462409HCID 23462409、化合物

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 6212Chloroform溶媒2 回

実験手順

A solution of 5 g of 5-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole in 100 ml of dry chloroform is dropped at room temperature into a solution of 20 ml of p-chlorobenzoyl chlorine and 12 ml of pyridine in 75 ml of dry chloroform. The solution is stirred for 30 minutes at room temperature and filtered. The filtrate is concentrated under vacuum; the residue obtained is dissolved in isopropanol and a stream of dry hydrogen chloride is bubbled into the solution to yield 6 g of 3-methyl-6-p-chlorobenzoyloxymethyl-imidazo-(2,1-b)thiazole hydrochloride; m.p. 198°-199°.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated under vacuum
  3. customthe residue obtained
  4. customa stream of dry hydrogen chloride is bubbled into the solution

出典と根拠

ORDレコード
ord-efff772f36774f189303e134455d81a4
出典データセット
uspto-grants-1981_05
特許番号
US04267339

反応ノート

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