(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol → (4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone

HRID 228796

反応式

HRID 228796 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[S:11][C:12]([CH3:16])=[C:13]([CH3:15])[N:14]=2)=[O:9])[O:5][C:6]=1[CH3:7]

参加物

4

反応物 1

HCID 23078354(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol

生成物 1

HCID 23078247(4,5-Dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone収率 97.1%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanol (945 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.5 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)(4,5-dimethylthiazol-2-yl)-methanone (910 mg, yield 97%).

後処理

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

出典と根拠

ORDレコード
ord-ff9c0126c13c495080a3055c9946dee9
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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