Methyl iodide → HCID 23078267、化合物

6-Fluoro-2-iodo-pyridin-3-ol (50 mg) was dissolved in acetonitrile (2 ml) to prepare a solution. Methyl iodide (148 mg) and potassium carbonate (87 mg) were added to the solution, and the mixture was stirred at room temperature overnight. The solvent was removed by distillation under the reduced pressure, water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with water and was dried over anhydrous magnesium sulfate, the solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform to give 6-fluoro-2-iodo-3-methoxypyridine (52 mg, yield 100%).

1. customto prepare a solution
2. customThe solvent was removed by distillation under the reduced pressure, water
3. additionwas then added to the residue
4. extractionthe mixture was extracted with chloroform
5. washThe chloroform layer was washed with water
6. dry with materialwas dried over anhydrous magnesium sulfate
7. customthe solvent was removed by distillation under the reduced pressure
8. customthe residue was purified by thin layer chromatography

ORDレコード

ord-5a4a2009f657482682cbaf6a43b28d3e

出典データセット

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07560558B2