Water → 3-(1-Methyl-1H-pyrazol-4-yl)propan-1-ol

HRID 2288223ノート

反応式

HRID 2288223 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9](OCC)=[O:10])[CH:4]=[N:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][OH:10])[CH:4]=[N:3]1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 18703402Ethyl 3-(1-methyl-1h-pyrazol-4-yl)propanoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 188014053-(1-Methyl-1H-pyrazol-4-yl)propan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To an ice-cooled solution of ethyl 3-(1-methyl-1H-pyrazol-4-yl)propionate (1.05 g) in tetrahydrofuran (10 ml) was added lithium aluminum hydride (0.22 g) under nitrogen atmosphere After the mixture was stirred for 30 minutes, water and 15% sodium hydroxide aqueous solution were added successively to the mixture. The resulting precipitates were filtered off through Celite® pad and the filtrate was extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give 3-(1-methyl-1H-pyrazol-4-yl)-1-propanol.

後処理

  1. customThe resulting precipitates
  2. filtrationwere filtered off through Celite® pad
  3. extractionthe filtrate was extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-1365775ca0334409a57305cc96abcc04
出典データセット
uspto-grants-2000_07
特許番号
US06087357

反応ノート

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