Sodium Hydroxide → 7-Methylquinolin-6-ol

HRID 228868

反応式

HRID 228868 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][CH:7]=[CH:6]2.[OH-].[Na+].C(=O)([O-])O.[Na+]>Br(O)(=O)=O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[N:9]=[CH:8][CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 155348986-Methoxy-7-methylquinoline

生成物 1

HCID 128389567-Methylquinolin-6-ol収率 47.2%

試薬・触媒・溶媒 1

HCID 24445Bromic acid溶媒

実験手順

6-Methoxy-7-methyl-quinoline (3 g) was added to an aqueous bromic acid solution (30 ml), and the mixture was heated under reflux for 7 hr. The reaction solution was cooled to room temperature, the aqueous layer was then neutralized with an aqueous sodium hydroxide solution and an aqueous sodium hydrogencarbonate solution. The organic layer was extracted with ether, the solvent was removed by distillation under the reduced pressure, and the residue was washed with cooled ether to give 6-hydroxy-7-methylquinoline (1.3 g, yield 47%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 7 hr
  3. extractionThe organic layer was extracted with ether
  4. customthe solvent was removed by distillation under the reduced pressure
  5. washthe residue was washed with cooled ether

出典と根拠

ORDレコード
ord-a88db85475c740678b93231be4afa665
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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