Sodium Iodide → 1-Iodo-2-methylpropyl 3-methylbutyrate

HRID 2290200ノート

反応式

HRID 2290200 の反応式
[I-:1].[Na+].[CH3:3][CH:4]([CH3:14])[CH2:5][C:6]([O:8][CH:9](Cl)[CH:10]([CH3:12])[CH3:11])=[O:7]>C(#N)C>[CH3:3][CH:4]([CH3:14])[CH2:5][C:6]([O:8][CH:9]([I:1])[CH:10]([CH3:12])[CH3:11])=[O:7]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 136045391-Chloro-2-methylpropyl 3-methylbutyrate

生成物 1

HCID 140301271-Iodo-2-methylpropyl 3-methylbutyrate収率 56.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Acetonitrile (200 ml) is warmed to 60° C. and in this solvent is dissolved 35 g of sodium iodide. To this solution is added 12 g of 1-chloro-2-methylpropyl 3-methylbutyrate as obtained by the above procedure (a), and the mixture is stirred for 40 minutes, poured into 500 ml of ice water and extracted with hexane. The extract is washed with water and then with 5% aqueous sodium thiosulfate and dried over anhydrous magnesium sulfate. The solvent is then distilled off under reduced pressure to give 10 g of 1-iodo-2-methylpropyl 3-methylbutyrate.

後処理

  1. customas obtained by the above procedure (a)
  2. extractionextracted with hexane
  3. washThe extract is washed with water
  4. dry with materialwith 5% aqueous sodium thiosulfate and dried over anhydrous magnesium sulfate
  5. distillationThe solvent is then distilled off under reduced pressure

出典と根拠

ORDレコード
ord-0e54df3271074ce0b8cf95ef37faf2df
出典データセット
uspto-grants-1986_10
特許番号
US04616008

反応ノート

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