Sodium Hydroxide → 4-[(1-Methyl-1H-tetrazol-5-yl)sulfanyl]butanoic acid
反応式
C([O:3][C:4](=[O:15])[CH2:5][CH2:6][CH2:7][S:8][C:9]1[N:13]([CH3:14])[N:12]=[N:11][N:10]=1)C.[OH-].[Na+]>C1COCC1>[CH3:14][N:13]1[C:9]([S:8][CH2:7][CH2:6][CH2:5][C:4]([OH:15])=[O:3])=[N:10][N:11]=[N:12]1参加物
4
実験手順
2.93 g of 4-(1-methyltetrazol-5-ylthio)-butyric acid ethyl ester are dissolved in 50 ml of THF, 15 ml of 1N NaOH are added and the whole is stirred for 3 hours at room temperature. Most of the THF is then concentrated by evaporation under reduced pressure in a rotary evaporator and the residue is washed with ethyl acetate. The aqueous solution is adjusted to pH 3 with 4N HCl and extracted three times with ethyl acetate. After drying over sodium sulphate and concentration by evaporation under reduced pressure, the pure title compound is obtained.
後処理
- concentrationMost of the THF is then concentrated by evaporation under reduced pressure in a rotary evaporator
- washthe residue is washed with ethyl acetate
- extractionextracted three times with ethyl acetate
- dry with materialAfter drying over sodium sulphate and concentration by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-8c68a04d750d416e8995293d97712081
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04616007
反応ノート
読み込み中…