(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone

HRID 229049

反応式

HRID 229049 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

参加物

4

反応物 1

HCID 23078465(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol

生成物 1

HCID 23078529(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone収率 81.1%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol (1.17 g) was dissolved in chloroform (30 ml) to prepare a solution. Manganese dioxide (4.69 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone (940 mg, yield 81%).

後処理

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

出典と根拠

ORDレコード
ord-d541dd2f8c2b40be824318bccb382ad9
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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