Phenol → Phenyl phenylacetate

HRID 2292121ノート

反応式

HRID 2292121 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([CH2:14][C:15](Cl)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl.N1C=CC=CC=1>[C:8]1([CH2:14][C:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 2

HCID 996PhenolHCID 7679Phenylacetyl chloride

生成物 1

HCID 164721Phenyl phenylacetate収率 95.6%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

Phenol (47.9 g) was dissolved in dichloromethane (250 ml) and pyridine (44.3 g). Phenylacetyl chloride (78.8 g) was added with stirring over 40 min., and the resulting mixture allowed to stand at room temperature for 1 hr. The mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution, and then once with saturated brine. The solution was dried and evaporated to give phenyl phenylacetate 103.3 g., m.pt 39°-41°.

後処理

  1. waitto stand at room temperature for 1 hr
  2. washThe mixture was washed sequentially with water, twice with dilute hydrochloric acid, once with dilute sodium hydroxide solution
  3. customThe solution was dried
  4. customevaporated

出典と根拠

ORDレコード
ord-021f2ec649524e079520067619bd1e06
出典データセット
uspto-grants-1989_01
特許番号
US04801593

反応ノート

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